The Struma Valley and Melnik wine region is home to a unique red grape variety cultivated there – Shiroka Melnishka Loza [Broad-Leaved Melnik]. Shiroka Melnishka Loza is an endemic species and all attempts to cultivate it outside of the region have failed. Shiroka Melnishka Loza is a late-ripening variety that is also challenging to grow. This is why several hybrid grape varieties, which aim to preserve the unique characteristics of this local grape variety, but at the same time make it easier to cultivate, were developed from Shiroka Melnishka Loza. Such hybrid varieties are: Melnik 82, Melnik Rouen and the most famous one Melnik 55 or Ranna Melnishka Loza [Early Melnik]. Typical local white grape varieties such as Sandanski Misket and Keratsuda could also be found in the Struma Valley and Melnik wine region. In addition to the grape varieties associated predominantly with the Struma Valley and Melnik wine region, other grape varieties grown here are: Mavrud (another native Bulgarian grape variety), Rubin (a hybrid Bulgarian grape variety), Cabernet Sauvignon, Cabernet Franc, Merlot, Syrah, Petit Verdot, Marselan, Nebbiolo, Sangiovese from the red varieties and Chardonnay, Sauvignon Blanc, Traminer, Viognier, Muscat Ottonel from the white varieties.